Extrasynaptic δ-subunit containing GABAA receptors

γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition. In specific brain cells, such as in hippocampus, one of subtypes GABAARs, δ subunit containing GABAARs (δ-GABAARs), is predominantly expressed and located extrasynaptic or perisynaptic positions. δ-GABAARs mediate a slow constant inhibitory current called tonic While inhibition critical excitability single neurons, accumulating data suggest that function broader includes an integrative role network oscillations. these open new horizons on neurobiology δ-GABAARs, complexity continues to challenge analysis their subtypes. This review will summarize knowledge molecular, cellular physiological characteristics during health disease.